Project 3
Intelligent Process Automation (IPA)
Prof. Dr. rer. nat. Gabriele Multhoff
Zentralinstitut für Translationale Krebsforschung der Technischen Universität München
Prof. Dr. med. Sebastian Kobold
Abteilung für Klinische Pharmakologie, KUM
Prof. Dr. med. Dr. rer. nat. Michael von Bergwelt-Baildon
Medizinische Klinik III, KUM
Prof. Dr. med. Tobias Feuchtinger
Universitätsklinikum Freiburg
Prof. Dr. med. Michael Hudecek
Medizinische Klinik II, UKW
Project Summary
This joint project between BMS and MIH is aiming at the preclinical and prospective clinical evaluation of the Intelligent Process Automation (IPA) platform, an automated, ultra-short, and closed-loop CAR T cell manufacturing platform.
The proposed project focuses on an in-depth preclinical investigation of functional, immunological, and cellular properties of IPA-generated T cell products in vitro as well as in humanized in vivo mouse models. The potential to generate a more homogeneous and effective T cell product using cutting-edge manufacturing methodologies (e. g. CRISPR-mediated targeted integration) in the automated IPA production system will be evaluated by comparison with conventionally produced cells.
The preclinical data will serve as the basis for initiating technology transfer activities to a pilot production facility to establish and validate the IPA process in a GMP-compliant manufacturing environment, followed by clinical evaluation, if applicable.
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